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Abstract
When tonsillar B cells were cultured in the presence of exogenous interleukin-6 (IL-6), a small portion of them differentiated into plasma cells which seemed to have IL-6 receptors on their surfaces. The number of plasma cells tended to be greater in the tonsils of children than in the tonsils of adults. When tonsillar cells collected by Ficoll-Conray's method were cultured in medium containing IL-6, T cells differentiated and the number of activated T cells increased. Of the four subsets of T cells, this effect of IL-6 was strongest on cytotoxic T cells. IL-6-mediated proliferation and activation of cytotoxic T cells tended to be greater in the tonsils of children than in those of adults. IL-6 is produced in some tonsillar macrophages. The number of macrophages producing IL-6 was very different in different subjects. However, the number of macrophages producing IL-6 in tonsils of children tended to be greater than the number in tonsils of adults.