Inhibitory Effect of Xian-Qing-Long-Tan Extract on Degranulation and Histamine Release from Rat Mast Cells

Tatsuzi Matsumoto Department of Otorhinolaryngology, Osaka Prefectural Hospital, Osaka, 558, Japan

Minoru Ishida Department of Otorhinolaryngology, Osaka Prefectural Hospital, Osaka, 558, Japan

Masanao Makino Osaka Prefectural Institute of Public Health, Osaka, 537, Japan

Tadayoshi Shibata Osaka Prefectural Institute of Public Health, Osaka, 537, Japan

Satoshi Ogino Department of Otorhinolaryngology, Osaka University Medical School, Osaka, 553, Japan

Toro Matsunaga Department of Otorhinolaryngology, Osaka University Medical School, Osaka, 553, Japan

Abstract

Xian-Qing-Long-Tang (XQLT), a Chinese medicine, is useful for treating allergic diseases. To demonstrate the anti-allergic effect of this drug we examined its effect on degranulation and histamine release from rat mast cells induced by antigen and compound 48/80. The effect on 48 h homologous passive cutaneous anaphylaxis (PCA) in rats was also studied. In the IgE antigen-antibody reaction using DNP-As, XQLT inhibited histamine release from rat mast cells, in vitro; it also inhibited 48 h rat homologous PCA reaction, in vivo. These results suggest that XQLT inhibits type 1 allergic reaction, and has effectiveness for allergic disease.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Inhibitory Effect of Xian-Qing-Long-Tan Extract on Degranulation and Histamine Release from Rat Mast Cells

Information for

Open access

Opportunities

Help and information

Inhibitory Effect of Xian-Qing-Long-Tan Extract on Degranulation and Histamine Release from Rat Mast Cells

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature