Effect of Transdermally Administered Scopolamine on the Vestibular System in Humans

Hideo Shojaku Department of Otolaryngology, Toyama Medical and Pharmaceutical University, Toyama

Yukio Watanabe Department of Otolaryngology, Toyama Medical and Pharmaceutical University, Toyama

Muneharu Ito Department of Otolaryngology, Toyama Medical and Pharmaceutical University, Toyama

Kanemasa Mizukoshi Department of Otolaryngology, Toyama Medical and Pharmaceutical University, Toyama

Kazuyoshi Yajima Department of Hygiene, Nihon University School of Medicine, Tokyo

Chiharu Sekiguchi National Space Development Agency of Japan, Tokyo, Japan

Abstract

In order to elucidate the effect of scopolamine on the vestibular system in humans, various experimentally—induced forms of nystagmus, i.e. caloric nystagmus, rotational nystagmus, optokinetic nystagmus, visual—vestibular interaction and optokinetic afternystagmus, were evaluated before and after the administration of two pieces of Scopoderm—TTS or placebo patches retro—auricularly. Scopolamine reduced the responses of both the caloric and optokinetic afternystagmus compared with the placebo. The possible action site of this drug is discussed.

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Effect of Transdermally Administered Scopolamine on the Vestibular System in Humans

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Effect of Transdermally Administered Scopolamine on the Vestibular System in Humans

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