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Abstract
This study investigated whether dominant negative summating potential (DNSP) is absent at all stages of induced hydrops development, including the early stages of hydrops formation. Electrocochleography (ECoG) was done 3 days to 20 weeks after obliteration of the endolymphatic sac in guinea pigs, by electrodes attached to the cochlear bony wall on the scala vestibuli of the basal turn. DNSP was noticed only during the early stages of endolymphatic hydrops formation, before hydrops was fully developed. There was no DNSP when the distension of Reissner's membrane was marked. Increased endolymphatic pressure and/or changes in biochemical composition were thought to be the causes of DNSP.