Eosinophil and Eosinophil Cationic Protein in Allergic Rhinitis

Takeshi Beppu Department of Otolaryngology, Yamagata University School of Medicine, Yamagata, 990-23, Japan

Nobuo Ohta Department of Otolaryngology, Yamagata University School of Medicine, Yamagata, 990-23, Japan

Songi Gon Department of Otolaryngology, Yamagata University School of Medicine, Yamagata, 990-23, Japan

Ken Sakata Department of Otolaryngology, Yamagata University School of Medicine, Yamagata, 990-23, Japan

Kazutoshi Inamura Department of Otolaryngology, Yamagata University School of Medicine, Yamagata, 990-23, Japan

Shigeru Fukase Department of Otolaryngology, Yamagata University School of Medicine, Yamagata, 990-23, Japan

Yo Kimura Department of Otolaryngology, Yamagata University School of Medicine, Yamagata, 990-23, Japan

Yoshio Koike Department of Otolaryngology, Yamagata University School of Medicine, Yamagata, 990-23, Japan

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Abstract

To evaluate the roles of eosinophils in allergic rhinitis, eosinophil cationic protein (ECP) levels in sera and nasal secretions were measured in 28 patients with allergic rhinitis. In patients, blood eosinophil counts and serum ECP levels were significantly higher than in controls (p < 0.05). However, there was no statistically significant correlation between blood eosinophil count and serum ECP level (r = 0.025). The number of eosinophils and the ECP level in nasal secretion were also measured. In patients, the ECP level increased with the number of eosinophils, and the ECP level in nasal secretion was significantly higher than in controls (p < 0.05). These results suggest that eosinophils and ECP play important roles in allergic rhinitis.

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Eosinophil and Eosinophil Cationic Protein in Allergic Rhinitis

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Eosinophil and Eosinophil Cationic Protein in Allergic Rhinitis

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