Predictable and Pseudo Random Saccades in Patients with Acoustic Neuroma

Abstract

We studied predictive and pseudo random saccades in patients with cerebellopontine angle tumor. Target for the saccades was a laser beam which was reflected on the wall in front of the subject. and the stimulus was controlled by a computer. The fixed target was spaced at a distance of ±30 to each side of the subject. The random saccades jumped 20°/40°/60° in an unpredictable manner. The saccade analysis program was based on pattern recognition. In the random saccade test none of the mean values of saccadic reaction time (SRT), saccadic accuracy (SA) and saccadic peak velocity (SPV) to the right or left direred significantly between the two groups. In the predictable saccade test there were statistically significant differences for certain variables: in right SRT (p < 0.01) and in left SRT (p < 0.01): in right SA (0.001 p < 0.01) and in left SA (p < 0.001). The mean peak velocity (right SPV and left SPV) did not differ significantly between the two groups. When the stimulus is predictable. the saccades in a healthy subject are more timely spaced and accurate than in a patient. When the stimulus is unpredictable, “the memory of the past” has no importance and cannot help in saccade programming. and variability in the healthy subjects increases.

Key Words:

• predictable saccades
• pseudo random saccades
• cerebellopontine tumors
• acoustic neuroma tumours
• healthy controls