In vivo Regeneration of Vestibular Hair Cells of Guinea Pig

Hideo Yamane The Department of Otolaryngology, Osaka City University Medical School, Osaka, 545, Japan

Takayuki Nakagawa The Department of Otolaryngology, Osaka City University Medical School, Osaka, 545, Japan

Hiroyoshi Iguchi The Department of Otolaryngology, Osaka City University Medical School, Osaka, 545, Japan

Shigetarou Shibata The Department of Otolaryngology, Osaka City University Medical School, Osaka, 545, Japan

Masahiro Takayama The Department of Otolaryngology, Osaka City University Medical School, Osaka, 545, Japan

Kiezou Nishimura The Department of Otolaryngology, Osaka City University Medical School, Osaka, 545, Japan

Yoshiaki Nakai The Department of Otolaryngology, Osaka City University Medical School, Osaka, 545, Japan

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Abstract

Recent studies have shown that inner ear sensory cells may regenerate in mammals as well as in birds. In this in vivo study we investigated the regeneration of vestibular hair cells in guinea pigs after gentamycin intoxication, and found that the vestibular sensory epithelia reproduced new hair cells 30 days after degeneration, due to 30 consecutive days of gentamycin treatment. From the regeneration pattern of sensory epithelia, the supporting cells were identified as the progenitors of hair cells.

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In vivo Regeneration of Vestibular Hair Cells of Guinea Pig

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In vivo Regeneration of Vestibular Hair Cells of Guinea Pig

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