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Original Article

Effects of Prostaglandins D, and E2 on Ciliary Beat Frequency of Human Upper Respiratory Cilia in Vitro

, , , &
Pages 438-442 | Received 25 Jul 1994, Accepted 26 Sep 1994, Published online: 08 Jul 2009
 

Abstract

Diminished mucociliary transport can occur in a type-I (Ig-E mediated) allergic reaction. We determined the effects of the allergy mediators prostaglandin D2 (PGD2) and prostaglandin E2 (PGE2) on the ciliary beat frequency (CBF) of human upper respiratory cilia in vitro. Human adenoid tissue was used as the source for ciliated epithelium. CBF was measured by a computerized photo-electric method. PGD2 (10−8-10−5 M, n = 7) showed no statistically significant effect on CBF. PGE2 (10−9 -10−16 M, n=10) caused a significant dose-dependent stimulation, with a maximum of 37% (ANOVA, p < 0.001). Thus prostaglandins D2 and E2 do not exert a direct negative influence on ciliary activity, which could account for a decrease in mucociliary transport. The stimulating effect of PGE2 may be relevant in promoting mucociliary clearance in vivo

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