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Original Article

Sodium and Potassium Currents of Type I Spiral Ganglion Cells from Rat

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Pages 552-560 | Received 29 Jun 1995, Accepted 17 Oct 1995, Published online: 08 Jul 2009
 

Abstract

Ion channel activity of acutely dissociated type I spiral ganglion cells isolated from rats was investigated using the whole-cell variation of the patch clamp technique. Tetrodotoxin-sensitive sodium current and tetraethylammonium-sensi-tive potassium current were recorded. With a holding potential of - 80 mV, peak sodium currents were generated by depolarizations to membrane potentials more positive than - 50 mV. Potassium currents were elicited at membrane potentials more positive than - 40 mV. Some cells which did not exhibit sodium current exhibited delayed rectifier potassium currents. Steady-state sodium channel inactivation curve yielded a slope of 12 mV and a half-inactivated potential of - 83 mV. Recovery from inactivation of the sodium channel proceeded with a fast and slow time course; recovery began as early as 0.8 ms and proceeded with a time constant of 7.5 ms. It is concluded that type I spiral ganglion cells are endowed with sodium and potassium channels which are responsible for generation and propagation of auditory nerve action potentials.

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