7
Views
6
CrossRef citations to date
0
Altmetric
Original Article

α1-Adrenergic Receptors in the Mammalian Cochlea

, &
Pages 710-713 | Received 25 Sep 1995, Accepted 05 Dec 1995, Published online: 08 Jul 2009
 

Abstract

Liu SY, Pitovski DZ, Shivapuja BG. α-adrenergic receptors in the mammalian cochlea. Acta Otolaryngol (Stockh) 1996; 116: 710-713.

The presence of α1, -adrenergic receptors in the mammalian cochlea has previously been suggested by physiological experiments using antagonists specific to the receptor. However, the characterises of adrenergic receptors in the cochlea have not been described. by employing [H]-prazosin, high affinity, specific binding sites with characteristics of α1, -adrenergic receptors have now been identified and characterized in the chinchilla cochlea. Analysis of the specific [H]-prazosin binding indicates that prazosin binds to a single class of high-affinity sites with a dissociation constant, kd, of 2.9 10−9 M and a maximum number of binding sites, Bmax, of 30 fmol/mg dry tissue. Furthermore, the binding characteristics suggest that these receptors may be related to the microvasculature of the cochlea. These results provide a rational basis for the observed actions of a-adrenergic drugs on the auditory system.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.