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Original Article

Uptake of Tetracycline in Otoconia of the Guinea Pig

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Pages 732-736 | Received 28 Aug 1995, Accepted 24 Oct 1995, Published online: 08 Jul 2009
 

Abstract

Zhang DM, Taktmida M, Harada Y. Uptake of tetracycline in otoconia of the guinea pig. Acta Otolaryngol (Stockh) 1996; 116:732-736.

Calcium ion turnover in the otoconia of adult guinea pigs was investigated by observing the uptake of tetracycline. Oral administration of tetracycline resulted in the deposition of tetracycline (fluorescence) on the outer surface of otoconia, indicating the occurrence of dynamic exchange and/or uptake of calcium ions in the otoconia. Prolonged administration of tetracycline induced with fluorescence deposition in the central portion as well as on the surface of the otoconia. These findings suggest the occurrence of neogenesis, regeneration and/or growth of otoconia even in adult animals.

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