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Acta Oto-Laryngologica Volume 116, 1996 - Issue 6
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Original Article

Growth Factors during Endotoxin-Induced Otitis Media

Thomas F. Demaria Otological Research Laboratories, Department of Otolaryngology, College of Medicine, the Ohio State University, Columbus, OH, 43210, USACorrespondence[email protected]
,
John M. Billy Otological Research Laboratories, Department of Otolaryngology, College of Medicine, the Ohio State University, Columbus, OH, 43210, USA
&
Daniel G. Danahey Otological Research Laboratories, Department of Otolaryngology, College of Medicine, the Ohio State University, Columbus, OH, 43210, USA
Pages 854-856 | Received 08 Jan 1996, Accepted 22 Feb 1996, Published online: 08 Jul 2009
 
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Abstract

DeMaria TF, Billy JM, Danahey DG. Growth factors during endotoxin-induced experimental otitis media.

The presence of growth factors in the middle ear fluid was examined during lipopolysaccharide-induced otitis media (OM) in the chinchilla. There was a progressive significant increase in the proliferative activity detected in the LPS-free MEF by five days in culture. We conclude that lps indirectly mediates hyperproliferative changes in the middle ear during OM by inducing growth factors.

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