Tinnitus Remission by Lidocaine Demonstrated by Auditory-evoked Magnetoencephalogram

Yosaku Shiomi Departments of Hearing and Speech Science, Kyoto University, Kyoto, Japan

Takashi Nagamine Departments of Brain Pathophysiology, Faculty of Medicine, Kyoto University, Kyoto, Japan

Nobuya Fujiki Departments of Hearing and Speech Science, Kyoto University, Kyoto, Japan

Shigeru Hirano Departments of Hearing and Speech Science, Kyoto University, Kyoto, Japan

Yasushi Naito Departments of Hearing and Speech Science, Kyoto University, Kyoto, Japan

Hiroshi Shibasaki Departments of Brain Pathophysiology, Faculty of Medicine, Kyoto University, Kyoto, Japan

Iwao Honjo Departments of Hearing and Speech Science, Kyoto University, Kyoto, Japan

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Abstract

An auditory-evoked magnetic field was recorded before and during tinnitus remission induced by an intravenous lidocaine injection. One and 4 kHz probe tones were presented monaurally in four tinnitus patients, and the responses were recorded using a 122-channel magnetometer. Three normal volunteers were also examined as controls. In tinnitus patients, the N100 m peak became sharper, while there was no marked change except for slight reduction in amplitude in normal subjects. Tinnitus remission by lidocaine may be related to attenuation of a masking-like effect of tinnitus on the sound-evoked responses.

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Tinnitus Remission by Lidocaine Demonstrated by Auditory-evoked Magnetoencephalogram

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Tinnitus Remission by Lidocaine Demonstrated by Auditory-evoked Magnetoencephalogram

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