Distribution of Endothelin-1-like Activity in the Cochlea of Normal Guinea Pigs

Ken Jinnouchi Department of Otolaryngology, Nippon Medical School, Tokyo, Japan

Shun-Ichi Tomiyama Department of Otolaryngology, Nippon Medical School, Tokyo, Japan

Ruby Pawankar Department of Otolaryngology, Nippon Medical School, Tokyo, Japan

Tetsuo Ikezono And Department of Otolaryngology, Nippon Medical School, Tokyo, Japan

Toshiaki Yagi Department of Otolaryngology, Nippon Medical School, Tokyo, Japan

Abstract

Distribution of endothelin-1 (ET-1) in the cochlea of normal guinea pigs was determined by immunohistochemistry. ET-1 activity was identified with the mouse anti-human ET-1 IgGl monoclonal antibody. ET-1 activity was distributed in the modiolus, spiral ligament, stria vascularis, spiral prominence, Reissner's membrane, supporting cells of the organ of Corti and spiral ganglion cells. These findings suggest that ET-1 may be involved in the regulation of fluid volume and ions of the cochlea.

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Distribution of Endothelin-1-like Activity in the Cochlea of Normal Guinea Pigs

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Distribution of Endothelin-1-like Activity in the Cochlea of Normal Guinea Pigs

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