Physiopathology of H, -Receptors and Pharmacology of Betahistine

Abstract

Van Cauwenberge PB, De Moor SEG. Physiopathology of H₃-_-receptors and pharmacology of betahistine. Acta Otolaryngol (Stockh) 1997: Suppl 526: 43–46.

This article reviews published research on the physiology of histamine H,-receptors. The function of this inhibitory autoreceptor. its localisation and influence on histaminergic neurones as well as histamine-controlled processes are presented together with the role of H₃-_-receptors in the vestibular system. In addition to a summary of the properties of the main H₃-_-agonists and -antagonists, the pharmacology of betahistine and its place in the treatment of vertigo are discussed.

Key Words:

• H₃-receptor
• histamine
• betahistine
• imapromidine
• thioperamide
• histaminergic neurons
• vestibular system