Expression of ER-DS and EGFr in Laryngeal Carcinoma and Pre-malignant Epithelium

Abstract

Maiorano E, Botticella MA, Marzullo A, Resta L. Expression of ER-D5 und EGFr in larvngeal carcinoma and pre-malignant epithelium. Acta Otolaryngol (Stockh) 1997; Suppl 527: 95-99.

The expression of estrogen receptors was biochemically assessed in a series of 46 cases of consecutive laryngeal carcinomas. ER-D5 and EGFr were also immunohistochemically detected in 44 and 46 cases respectively. There was no correlation between the expression of these molecules and the typical anatomo-clinical prognostic parameters of laryngeal tumors. The concomitant expression of estrogen receptors, ER-D5 and EGFr was also investigated in normal, hyperplastic and dysplastic epithelium. An increasing expression of ER-D5 and EGFr from normal to hyperplastic and dysplastic epithelium was noted. These data suggest a possible role of hormone receptors in the laryngeal carcinogenesis.

Key Words:

• ER-D5
• EGFr
• laryngeal carcinoma
• larynx
• immunohistochemistry