Azathioprine with Cortisone in Treatment of Hearing Loss in only Hearing Ear

Abstract

A sudden or progressive hearing loss in the only hearing ear is an otologic emergency, in which therapeutic possibilities are limited. We describe results of immunosuppressive therapy in 10 patients with one deafened ear either due to cochlear hydrops or Meniere's disease, who developed progressive or fluctuant hearing loss in the only hearing ear. The perilymphatic fistula was excluded with tympanoscopy. Azathioprine (25 mg t.i.d.) with prednisone (initial dose 20–40 mg with daily dose of 5–15 mg/day) was used. The hearing of 6 subjects responded to treatment. The initial pure tone audiogram (PTA) at speech frequencies of the “only hearing ear” was 57.3 dB HL with speech discrimination score (SDS) of 85%. The hearing improvement occurred successively within days or weeks. The average improvement of PTA was 22.4 dB HL after the mean treatment period of 5 weeks. In contralateral ear (the average PTA and SDS were 72.5 dB HL and 28% respectively) the mean improvement in PTA was insignificant (4.4 dB). In 5 patients with vertigo it was improved in 3 cases. Cortisone alone or with combination of cyclophosphamide or ciclosporine was not effective in our hands.

Key Words:

• autoimmune inner ear disease
• immunotherapy
• sudden deafness
• progressive hearing loss