SYNOPSIS
Symptom intensities for a manic-depressive patient were recorded over a period of ten months, with 83 occasions of testing. On each occasion, a personal questionnaire covering twenty symptoms was presented, following Shapiro's method. Three clusters were obtained which involved symptoms of depression, agitation and hypomania. The time series for each cluster showed somewhat irregular cyclic trends. Various treatments appeared to modify, but did not prevent, the periodic changes in mood. Depression and hypomania were negatively related clusters, rather than complementary aspects of a single dimension. Agitation was correlated with depression, but nevertheless showed a distinct trend as a separate cluster. Implications for the symptomatology of depression were found.