Treatment Of Acute Methylmercury Ingestion By Hemodialysis With N-Acetylcysteine (Mucomyst) Infusion And 2,3-Dimercaptopropane Sulfonate

Mary Ellen Lund Departments of Pediatrics and Pharmacology University of Arizona, Tucson, Arizona, 85724

William Banner Departments of Pediatrics and Pharmacology University of Arizona, Tucson, Arizona, 85724

W. Clarkson Thomas Department of Radiation Biology and Biophysics Division of Toxicology University of Rochester, Rochester, New York, 14642; Departments of Pediatrics and Pharmacology University of Arizona, Tucson, Arizona, 85724

Maths Berlin Institute of Environmental Hygiene University of Lund, Lund, SWEDEN; Departments of Pediatrics and Pharmacology University of Arizona, Tucson, Arizona, 85724

Abstract

A case of acute methylmercury ingestion was treated sequentially with oral D-penicillamine, hemodialysis during N-acetylcysteine (NAC) infusion, and 2,3-dimercaptopropane sulfonate (DMPS) an experimental oral agent. Urinary organic mercury elimination rate increased almost 40-fold during and 84-fold after hemodialysis with NAC infusion, compared with elimination during initial D-penicillamine therapy. Mean clearance during hemodialysis was only 13 ml/min with an

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Treatment Of Acute Methylmercury Ingestion By Hemodialysis With N-Acetylcysteine (Mucomyst) Infusion And 2,3-Dimercaptopropane Sulfonate

Information for

Open access

Opportunities

Help and information

Treatment Of Acute Methylmercury Ingestion By Hemodialysis With N-Acetylcysteine (Mucomyst) Infusion And 2,3-Dimercaptopropane Sulfonate

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature