Tonotopic Mapping in Auditory Cortex of the Adult Chinchilla with Amikacin-Induced cochlear Lesions: Mapeo tonotópico de la corteza auditiva de la chinchilla adulta con lesiones cocleares inducidas con amikacina

Abstract

We have found a reorganization of tonotopic maps (based on neuron response thresholds) in primary auditory cortex of the adult chinchilla after amikacin-induced basal cochlear lesions. We find an over-representation of a frequency that corresponds to the border area of the cochlear lesion. The reorganization observed is similar in extent to that previously seen in a developmental model. The properties of neurons within the over-represented area were investigated in order to determine whether their responses originated from a common input (an indication of true plasticity) or represented only the result of truncating the activity of the sensory epithelium (“pseudo-plasticity”). Some aspects of our data fit with a true plasticity model and indicate the potential for the deafferented cortex of the mature cortex to regain connections with the surviving sensory epithelium.

Key Words:

• Single-unit electrophysiology
• Cortical mapping
• Auditory cortex
• Plasticity
• Aminoglycoside
• Amikacin
• Ototoxicity
• Scanning electron microscopy
• Cochleogram
• Auditory brainstem response audiogram