Does Incubator Noise Increase Risks of Aminoglycoside Ototoxicity?

Abstract

One group of newborn rats were given 50 mg/kg gentamicin for 20 days, 8 days afterbirth and were housed during the treatment in a regular incubator. They were compared to a similar group housed in regular cages and to two groups of unintoxicated newborn rats, one being exposed to the incubator noise and one being unexposed. Incubator noise was found to have no influence on gentamicin ototoxicity and to induce only a temporary threshold shift.

Key Words:

• Incubator noise
• Aminoglycosides
• Ototoxicity