Effects of Testosterone and Clomiphene on Spectral Eeg and Visual Evoked Response in A Young Man with Posttraumatic Epilepsy

Abstract

The effects of testosterone and clomiphene on epilepsy was studied in a young man with posttraumatic seizures. in the control period, digital EEG and visual evoked potentials (VEPs) were recorded under carbamazapine therapy. After testosterone (T), seizures lessened and almost disappeared; the theta, delta, alpha, and beta powers decreased; VEPs increased. After clomiphene, VEPs considerably increased in size; clinical picture slightly improved; EEG power spectrum remained unchanged. It was suggested that T may be beneficial for epilepsy treatment by suppressing the EEG synchronization (slow wave activity) and attenuating the entropy state of the epileptic brain.

Key Words:

• Testosterone
• Clomiphene
• Seizure
• EEG
• Evoked potential
• Brain