Gaba Uptake by Rabbit Restiform Body Homogenates

Abstract

Restiform body (inferior cerebellar peduncle) preparations were obtained from rabbit brain stem slices and homogenized.

When challenged with labelled GABA, these homogenates took it up briskly. We have characterized pharmacologically this uptake which resulted almost equally neuronal and glial. The neuronal component of the GABA uptake might be due to the adjacent cochlear nuclei coming along in the preparations, whereas the glial component probably belongs to the restiform body proper.

Another possibility is that actually both components are due to the myelinated fibers and glia which make up the restiform body.

Key Words:

• Inferior cerebellar peduncle
• GABA uptake
• Glial uptake
• Neuronal uptake