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Abstract
Background: Two single-nucleotide polymorphisms rs11833579 and rs12425791 located on chromosome 12p13 were reported to be associated with ischemic stroke in Caucasians. In the present study, we investigated whether the single-nucleotide polymorphism rs12425791 was associated with ischemic stroke in Chinese populations. Methods:We carried out a case–control study examining a total of 166 Guangxi Han patients with ischemic stroke and 192 healthy controls. We also performed a meta-analysis of the data from our study and those from published studies to investigate whether an association between rs12425791 and ischemic stroke could be detected in Chinese populations. Results: There was no statistically significant association between the single-nucleotide polymorphism rs12425791 and ischemic stroke in the Guangxi Han population. Our meta-analysis also found no significant association between rs12425791 and ischemic stroke in Chinese populations [allelic model odds ratio (OR) = 1.01, 95% confidence interval (CI), 0.96–1.07; dominant model OR = 1.01, 95%CI, 0.94–1.10; recessive model OR = 1.00, 95%CI, 0.86–1.17]. Conclusions: The single-nucleotide polymorphism rs12425791 does not confer a substantial risk for ischemic stroke in Chinese populations.
Notice of Correction
The version of this article published online ahead of print on 04 Feb 2013 contained an error in the author list. The co-corresponding authors were wrongly marked as Lian Gu and Li Su but it should have read Li Su and Nong Tang. The error has been corrected for this version.