Impairment in Auditory and Visual Function Follows Perinatal Viral Infection in the Rat

Arnold Campo And Center for Brain Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642

Manuel del Cerro Center for Brain Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642

John A. Foss Department of Psychology, College of Arts and Science, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642

James R. Ison Department of Psychology, College of Arts and Science, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642

J. L. Orr Department of Psychology, College of Arts and Science, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642

P. H. Warren Department of Psychology, College of Arts and Science, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642

A. A. Monjan Department of Epidemiology, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, MD, 21205View further author information

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Abstract

Acoustic startle reflexes are elicited by intense tone bursts but inhibited if weak bursts precede reflex elicitation. Rats were infected by intracerebral inoculation with lymphocytic choriomeningitis virus (LCMV) at birth. Compared to control animals, infected animals had higher elicitation and inhibition thresholds and showed recruitment at intense stimulus levels. Histopathology revealed both cochlear and retinal degeneration. Like some infectious agents in humans, perinatal exposure to LCMV in the rat yields a severe polysensory neuropathy.

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A. A. Monjan

Joyce Laing works in the Department of Child and Family Psychiatry, Playfield House, Cupar, Fife, and is a Consultant Art Therapist to Psychiatric Hospitals and Prisons and Chairwoman of the Scottish Society of Art and Psychology.

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Impairment in Auditory and Visual Function Follows Perinatal Viral Infection in the Rat

Notes on contributors

A. A. Monjan

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Impairment in Auditory and Visual Function Follows Perinatal Viral Infection in the Rat

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A. A. Monjan

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