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International Journal of Neuroscience Volume 38, 1988 - Issue 3-4
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Original Article

Immunodeficient Dwarfism in Dogs: A Model for Neuroimmunomodulation

James A. Roth Department of Veterinary Microbiology and Preventive Medicine; The Immunobiology Program; and the Department of Veterinary Clinical Sciences, Iowa State University, Ames, IA, 50011
,
Belinda Lawler Goff Department of Veterinary Microbiology and Preventive Medicine; The Immunobiology Program; and the Department of Veterinary Clinical Sciences, Iowa State University, Ames, IA, 50011
&
William E. Monroe Department of Veterinary Microbiology and Preventive Medicine; The Immunobiology Program; and the Department of Veterinary Clinical Sciences, Iowa State University, Ames, IA, 50011
Pages 443-454 | Received 05 Jun 1987, Published online: 07 Jul 2009
 
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Abstract

This paper discusses the use of dogs as experimental models for neuroimmunomodulation and compares immunodeficient dwarfism in dogs to that in rodents. Immunodeficient dwarfism in dogs is reviewed including descriptions of the clinical syndrome, immunologic characteristics, neuroendocrine abnormalities, thymus histopathology, and therapy.

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