Methylprednisolone Treatments Alter Apomorphine-Induced Circling in the Rat Model of 6-Hydroxydopamine-Induced Striatal Denervation

Jeffrey Thomas Department of Neurology, College of Physicians and Surgeons, Columbia University, 630 West 168th St., New York, New York, 10032

Vernice Jackson-lewis Department of Neurology, College of Physicians and Surgeons, Columbia University, 630 West 168th St., New York, New York, 10032

Stanley Fahn Department of Neurology, College of Physicians and Surgeons, Columbia University, 630 West 168th St., New York, New York, 10032

Jean Lud Cadet Department of Neurology, College of Physicians and Surgeons, Columbia University, 630 West 168th St., New York, New York, 10032

Abstract

Intrastriatal injection of 6-hydroxydopamine causes significant depletion of dopamine which is associated with contralateral apomorphine-induced rotation in rats. Pretreatment with methylprednisolone (MP) causes almost complete elimination of the apomorphine-induced behavioral responses. In addition, there were significant differences between the lateralization effects of the neurotoxin on the levels of striatal dopamine. These results suggest that MP may have ameliorative effects against the motoric behavioral changes associated with the intrastrial injection of 6-OHDA.

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Methylprednisolone Treatments Alter Apomorphine-Induced Circling in the Rat Model of 6-Hydroxydopamine-Induced Striatal Denervation

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Methylprednisolone Treatments Alter Apomorphine-Induced Circling in the Rat Model of 6-Hydroxydopamine-Induced Striatal Denervation

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