Neurophysiology and Neurochemistry of Drug Dependence: A Review

Abstract

To understand the neurophysiological and neurochemical mechanisms of drug dependence, the functional significance of dopamine, noradrenaline and endogenous opioid peptides in the mediation of natural, self-stimulation and pharmacological reinforcement are discussed. Data on search of system(s), mediator(s) and neurons of reinforcement as well as my own notions on reinforcement as a critical element in organization and regulation of the organism's adaptive activity in variable environments are presented. The role of chronic drug-induced stable modification of central neurochemical systems' functioning as a basis for the alteration of endogenous reinforcement processes and raising drug dependence are examined in detail for main addictive drugs, opiates and psychomotor stimulants.

Key Words:

• reinforcement
• opiates
• psychomotor stimulants
• dopamine
• noradrenaline
• endogenous opioid peptides
• freedom — servitude