![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
The increase in 36Cl n → out permeation across plasma membranes from the Deiters' neurons by GABA on the cytoplasmic side is modulated by Ca++. The GABA stimulation was maximal with Ca++ on the intracellular side at the physiologically likely concentration of 3 × 10−8 M. A lower effect was found in the 10−7 −10−5 M [Ca++]; range with a total disappearance of it at [Ca++] of. 2 mM. This Cl− extrusion mechanism is likely to be involved in the establishment of a C1- out → in electrochemical gradient. Modulation of it by intracellular Ca++transients may be of physiological importance