Tremor-Bursts Induced by a Combined Application of Chlorpromazine and Pentobarbital in Guinea Pigs are Asymmetrically Influenced by Right- and Left-Brain Lesions

Abstract

The effect of right- and left-brain lesions on pentobarbitone-chlorpromazine induced tremor-bursts was studied in guinea pigs. The left-brain transections did not affect these tremor bursts except postthalamic sections, which caused a complete disappearance of extensor jerks with coinciding tremors at four legs. These tremor bursts simultaneously occurring at four legs completely disappeared after a right-forebrain transection at the level of the rostral striatum. Extensor jerks without tremors continued to occur, however. It is concluded that the postural system is asymmetrically controlled and the rostral right brain is responsible for the tonic postural activity in guinea pigs

Key Words:

• Tremor
• pentobarbital
• chlorprornuzine
• cerebral lateralization
• guinea pig