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Abstract
Extracellular single unit recordings were made from spinal dorsal horn wide dynamic range neurons in spinal transected, urethane-anesthetized rats. The unit discharges elicited by noxious electrical stimulation of the hind paw were suppressed by electroacupuncture (15Hz, 0.3ms, 3mA, 30min) placed at the hind leg points (S-36 and SP-6). Local spinal superfusion with naloxone (20μg/15μl) or CCK-8 (10ng/15μl) attenuated, whereas CCK-B receptor antagonist L365, 260 (2.5μg/15nl) enhanced the electroacupuncture effect. These findings provide further evidence for the notion that CCK-8, in the spinal cord, functions as an antiopioid substrate that antagonizes opioid- or electroacupuncture-induced analgesia.