Monoclonal Antibodies Against Antigens Of The Human Platelet Surface: Preparation And Properties

Heddy Zola Department of Clinical Immunology, Flinders Medical Centre and Flinders University of South Australia, Adelaide

P. J. McNamara Department of Clinical Immunology, Flinders Medical Centre and Flinders University of South Australia, Adelaide

I. G. R. Beckman Department of Clinical Immunology, Flinders Medical Centre and Flinders University of South Australia, Adelaide

D. A. Brooks Department of Clinical Immunology, Flinders Medical Centre and Flinders University of South Australia, Adelaide

P. J. Macardle Department of Clinical Immunology, Flinders Medical Centre and Flinders University of South Australia, Adelaide

J. Bradley Department of Clinical Immunology, Flinders Medical Centre and Flinders University of South Australia, Adelaide

K. Goodall Department of Clinical Haematology, Flinders Medical Centre and Flinders University of South Australia, Adelaide

J. Skinner Department of Pathology, Flinders Medical Centre and Flinders University of South Australia, Adelaide

R. Collins Division of Immunology, Pathology Department, Royal Brisbane Hospital, Brisbane

M. C. Berndt Department of Medicine, University of Sydney, Westmead Hospital, Sydney

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Abstract

Three monoclonal antibodies, FMC24, 25 and 27, reactive with human platelets, are described. In normal blood the 3 antibodies are specific for platelets, but FMC27 reacts with leukemic blast cells in a proportion of acute leukemias. FMC25 precipitates the platelet membrane glycoprotein lb and a glycoprotein of molecular weight 22,000. The antibodies show different effects on platelet aggregation.

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Monoclonal Antibodies Against Antigens Of The Human Platelet Surface: Preparation And Properties

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Monoclonal Antibodies Against Antigens Of The Human Platelet Surface: Preparation And Properties

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