Abstract
The growing use of mammography has resulted in increasing numbers of impalpable breast lesion specimens requiring histopathological assessment. The examination of such specimens may be very time-consuming as multiple levels of many tissue blocks may need to be studied. Two grid localization methods are compared with a serial slicing method in an attempt to determine an efficient manner of identifying the impalpable lesion, and thus minimizing unnecessary processing. The serial slicing technique gives excellent radiological-pathological correlation, but is probably too complex for routine use. A simple cardboard and metal staple device gives very good localization, and is quick, easy, and cheap to use.