Decreased synovial fluid omentin-1 concentrations reflect symptomatic severity in patients with knee osteoarthritis

Abstract

The aim of this study was to measure omentin-1 concentrations in serum and synovial fluid (SF) of knee osteoarthritis (OA) patients and to investigate their correlation with patient-reported symptomatic severity. We enrolled 263 knee OA patients and 62 healthy controls. We collected Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores from OA patients and measured omentin-1 concentrations in serum and SF by enzyme-linked immunosorbent assay (ELISA). Our results demonstrated that omentin-1 concentrations in SF but not serum were independently and negatively correlated with self-reported greater pain and physical disability in OA patients. Omentin-1 in SF might serve as a potential biomarker for reflecting the symptomatic severity of OA.

Key Words::

• Knee
• osteoarthritis
• adipokine
• omentin-1
• biomarker

Declaration of interest: The authors report no conflict of interest. The authors alone are responsible for the content and writing of the article.