A Procoagulant from Human Postpartum Serum II. Isolation and properties

Abstract

A method is described for purification of a procoagulant from postpartum serum. The purification includes fractionation according to Cohn, precipitation with ammonium sulphate and high-speed centrifugation. The procoagulant is not present in normal serum. The purified procoagulant has several similarities to tissue thromboplastin. It is concluded to be a tissue thromboplastin derived from placental tissues during delivery.

Key Words:

• Amino acid sequence
• blood coagulation
• blood coagulation factors
• factor V
• factor VII
• factor X
• placenta
• prothrombin
• thrombin
• thromboplastin