Abstract
Norum, K. R. & Gjone, E. The Influence of Plasma from Patients with Familial Plasma Lecithin:Cholesterol Acyltransferase Deficiency on the Lipid Pattern of Erythrocytes. Scand. J. clin. Lab. Invest. 22, 94-98, 1968. Patients with familial plasma lecithin: cholesterol acyltransferase deficiency have increased amounts of cholesterol and lecithin in their erythrocytes. When these erythrocytes were incubated with normal plasma, either fresh or heat-inactivated, a decrease in the erythrocyte cholesterol and lecithin took place. When, on the other hand, normal erythrocytes were incubated with plasma from the patients an uptake of cholesterol from the plasma was observed. It is concluded that the pathological lipid pattern of the erythrocytes from the patients is secondary to the abnormal high ratio of free/esterified cholesterol in their plasma due to the lack of lecithin: cholesterol acyltransferase.