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Original Article

Detection of Monoclonal IgM Subunits in Macroglobulinemia Waldenström

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Pages 199-204 | Received 08 May 1969, Accepted 27 Aug 1969, Published online: 08 Jul 2009
 

Abstract

A serum containing an M-component of IgM type gave on immunoelectrophoresis a biarcuate precipitation line. The anodal arch was produced by subunits of IgM, the other, by polymeric (17 S) IgM. The subunits combined in other optimal proportions with anti IgM than polymeric IgM as shown by e.g. immunoelectrophoresis and antigen-antibody crossed electrophoresis. Changes in immunoprecipitation patterns after reduction with mercaptoethanol of the cathodal arch to a mobility more equal to the anodal arch is one way to trace IgM subunits in plasma.

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