Enzymatic and Immunochemical Estimation of C'l Esterase Inhibitor in Sera from Patients with Hereditary Angioneurotic Edema

Abstract

Immunochemical and enzymatic estimation of C'l esterase inhibitor showed a correlation between the values for normal sera and heparin plasma but not for EDTA plasma. With the enzymatic method, EDTA plasma showed lower values than those obtained with sera and heparin plasma. Low values were found in 14 of 17 patients with hereditary angioneurotic edema. In 3 of these sera the values obtained with the two techniques disagreed; all 3 showed low inhibiting capacity but elevated or normal content of inhibitor protein.

Key Words:

• Angioneurotic edema
• blood protein
• complement
• enzyme inhibitors
• immunoelectrophoresis
• serum globulin