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Scandinavian Journal of Clinical and Laboratory Investigation Volume 24, 1969 - Issue 3
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Original Article

Methodological Studies of the Distribution of Hydroxyproline in Human Serum

Elisabeth Arnold The Department of Pharmacology and Medical Dept. A Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
,
E. Hvidberg The Department of Pharmacology and Medical Dept. A Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
&
S. Rasmussen The Department of Pharmacology and Medical Dept. A Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Pages 231-235 | Received 04 Jun 1969, Accepted 27 Aug 1969, Published online: 08 Jul 2009
 
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Abstract

A procedure for separation of hydroxyproline-containing fractions in blood serum by Sephadex G-200 ® is described and applied to human serum. The major part of the serum hydroxyproline is a part of, and not only associated with, the protein fractions. The pattern of distribution seemed to be fairly uniform in a limited number of healthy volunteers. Studies of this distribution pattern might be useful in the investigation of the collagen metabolism in certain disorders and drug treatments.

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