Thrombin-Induced Vasoconstriction in the Pulmonary Circulation: Scandinavian Journal of Clinical and Laboratory Investigation: Vol 27, No 4

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Abstract

Supernatants from thrombin-treated cell suspensions acted as vasoconstrictors on isolated perfused dog lung lobes. The vasoconstriction was due to serotonin released from the platelets. Thrombin caused an increase of pulmonary vascular resistance in vivo. This increase was markedly reduced by the serotonin antagonist methysergide.

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Thrombin-Induced Vasoconstriction in the Pulmonary Circulation

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Thrombin-Induced Vasoconstriction in the Pulmonary Circulation

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