Typing of Fibrinogen Degradation Products in Urine in Various Clinical Disorders

Abstract

Fibrinogen degradation products (FDP) in urine were typed with a modification of Niléhn's immunochemical method, using agarose plates containing antifibrinogen, anti-D, and anti-E, respectively. The appearance of single or double peaks in the various plates will decide the type(s) and concentration(s) of the FDP. D- and E-fragments, but no HMWS were demonstrated in urine from 20 of 28 patients receiving thrombolytic therapy. HMWS were found in urine from 12 patients with chronic uremia, 3 patients with acute uremia, and 11 patients after kidney transplantation. In most cases the concentration of FDP in the urine was much higher than in the serum. The demonstration of HMWS in urine may indicate a renal disease with fibrin deposits in the kidney, and the HMWS may be the result of lysis of these fibrin deposits. D- and E- fragments in the urine probably originate most often from fibrinolysis in the blood and clearance of these products in the kidney and not from lysis of fibrin deposits in the kidney.

Key Words:

• Fibrinogen degradation products
• fibrinolysis
• renal diseases
• thrombolytic therapy