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Scandinavian Journal of Clinical and Laboratory Investigation Volume 28, 1971 - Issue 1
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Original Article

The Galactose Utilization Rate in Liver Slices from Man and Rat and Its Relation to the Lactate/Pyruvate Ratio of the Medium

N. Tygstrup Division of Hepatology, Medical Department A, Surgical Department C, Rigshospitalet, Institute of Biochemistry A, University of Copenhagen, Copenhagen, Denmark
,
A. Schmidt Division of Hepatology, Medical Department A, Surgical Department C, Rigshospitalet, Institute of Biochemistry A, University of Copenhagen, Copenhagen, Denmark
&
H. I. D. Thieden Division of Hepatology, Medical Department A, Surgical Department C, Rigshospitalet, Institute of Biochemistry A, University of Copenhagen, Copenhagen, Denmark
Pages 27-31 | Received 11 Feb 1971, Accepted 24 Apr 1971, Published online: 08 Jul 2009
 
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Abstract

The effect on the galactose utilization rate of changes in the lactate/pyruvate concentration ratio produced by addition of lactate, pyruvate, and ethanol was studied in liver slices from rat and man. The galactose utilization rate of human liver slices was twice as great as that of rat liver slices. Addition of pyruvate increased the utilization rate, lactate caused no significant change, and ethanol decreased it to about 20 per cent. Combinations of the additions caused intermediate changes, irrespective of the resulting lactate/pyruvate ratio. Evidence for a dissociation between cytoplasmic NADH/NAD ratio and lactate/pyruvate concentration ratio in the medium is produced.

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