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Scandinavian Journal of Clinical and Laboratory Investigation Volume 28, 1971 - Issue 1
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Original Article

The Effect of Testosterone in Pharmacological Doses on Plasma Volume and on Some Serum Proteins in Patients with Sickle Cell Anemia and in Sexually Impotent Men

B. Lundh Hematology Research Laboratory, Presbyterian-University of Pennsylvania Medical Center, Department of Medicine, University of Pennsylvania Medical School, Philadelphia, USA
&
F. H. Gardner Hematology Research Laboratory, Presbyterian-University of Pennsylvania Medical Center, Department of Medicine, University of Pennsylvania Medical School, Philadelphia, USA
Pages 71-78 | Received 27 Mar 1971, Accepted 14 May 1971, Published online: 08 Jul 2009
 
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Abstract

Serum levels of 13 plasma proteins and the plasma volumes were estimated in 10 patients with sickle cell anemia (SCA) and in 6 sexually impotent males (SIM) before and during treatment with high-dose androgens. In both groups an increase was seen for α1-antitrypsin and orosomucoid. In the SCA group a marked increase was found for hemopexin. Haptoglobin could be demonstrated in some samples during treatment. In the SIM group hemopexin did not change but haptoglobin increased. On androgens plasma volume decreased in the SCA and increased in the SIM group.

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Related Research Data

Testosterone therapy and prostate cancer--safety concerns are well founded.
Source: Springer Science and Business Media LLC

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