Rates of Elimination of Sorbitol and Ethanol in the Choline-Deficient Fatty Liver

Abstract

Fatty liver produced by a low-protein high-fat choline-deficient diet was shown to eliminate sorbitol at a significantly decreased rate both in vivo and in vitro in male Wistar rats. This effect was demonstrated to be due to choline deficiency and not to the low-protein high-fat diet. Ethanol-oxidizing capacity as referred to the protein content of the liver in the choline deficient rats was the same as in control rats. On the other hand, choline supplementation to the low-protein high-fat diet seemed to decrease the ethanol-oxidizing capacity of the liver.

Key Words:

• Alcohol ethyl
• choline chloride
• fatty liver
• liver
• sorbitol