Pulmonary Effects of Induced Platelet Aggregation. Intravascular Obstruction or Vasoconstriction?

K. Radegran Surgical Research Laboratory, Thoracic Clinic, Karolinska Hospital, Stockholm, Sweden; Dept. of Surgery I, Sahlgrenska Hospital, Gothenburg, Sweden

S. E. Bergentz Surgical Research Laboratory, Thoracic Clinic, Karolinska Hospital, Stockholm, Sweden; Dept. of Surgery I, Sahlgrenska Hospital, Gothenburg, Sweden

D. H. Lewis Surgical Research Laboratory, Thoracic Clinic, Karolinska Hospital, Stockholm, Sweden; Dept. of Surgery I, Sahlgrenska Hospital, Gothenburg, Sweden

U. Ljungqvist Surgical Research Laboratory, Thoracic Clinic, Karolinska Hospital, Stockholm, Sweden; Dept. of Surgery I, Sahlgrenska Hospital, Gothenburg, Sweden

P. Olsson Surgical Research Laboratory, Thoracic Clinic, Karolinska Hospital, Stockholm, Sweden; Dept. of Surgery I, Sahlgrenska Hospital, Gothenburg, Sweden

Abstract

Protamine was infused with or without prior injection of acetylsalicylic acid (ASA) in dogs. Platelets were labelled with ⁵¹Cr. There was significantly less rise in pulmonary arterial pressure in ASA dogs (+ 3 mm Hg) than in control dogs (+ 13 mm Hg). The platelet particle concentration and ⁵¹Cr activity of blood decreased more than 90%, and the ⁵¹Cr activity of lung tissue increased tenfold in both groups. Pulmonary vasoconstriction rather than intravascular obstruction caused the rise in pulmonary arterial pressure.

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Pulmonary Effects of Induced Platelet Aggregation. Intravascular Obstruction or Vasoconstriction?

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Pulmonary Effects of Induced Platelet Aggregation. Intravascular Obstruction or Vasoconstriction?

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