Oxygen-Linked Hydrogen Ion Binding of Human Hemoglobin. Effects of Carbon Dioxide and 2,3-Diphosphoglycerate: IV. Thermodynamical Relationship between the Variables

Abstract

Human erythrocyte fluid is described as a thermodynamical system. As independent variables are chosen: Oxygen saturation, pH, pCO₂, and total DPG concentration. The dependent variables are: pO₂, titratable base, total CO₂, and DPG activity. Four differential equations relating these variables constitute the basis of the description. 10 different partial differential coefficients between the variables are described. All the remaining 310 different partial differential coefficients may be derived in terms of these 10.

Key Words:

• Acid-base equilibrium
• Bohr effect
• carbamino-CO₂
• carbon dioxide
• 2,3-diphosphoglycerate
• Haldane effect
• hemoglobin
• hydrogen ion concentration
• oxygen