Pulmonary Gas Exchange after Intravenous Injection of ^99mTc-Sulphur-Colloid Albumin Macroaggregates for Lung Perfusion Scintigraphy

Abstract

Pulmonary gas exchange in the sitting position at rest and during 200 kpm/min steady state exercise has been examined in 13 patients with unior bilateral lung disease before and within 2 hours after intravenous injection of 0.02 mg ^99mTc-sulphur-colloid albumin macroaggregates/kg body weight for routine lung scintigraphy. The investigated parameters, including the alveolar-arterial Po₂difference and the physiological dead space, remained essentially unchanged. Thus, lung scintigraphy with 0.02 mg particles/kg does not influence pulmonary function.

Key Words:

• Lung perfusion scintigraphy
• pulmonary gas exchange
• ^99mTc-sulphur-colloid albumin macroaggregates