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Scandinavian Journal of Clinical and Laboratory Investigation Volume 30, 1972 - Issue 1
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Original Article

Renal Tubular Secretion of Erythropoietin

R. W. Skoglund Pediatric Research Institute, Rikshospitalet, Oslo, Norway; Department of Urology, University of Washington Medical School, Seattle, Washington, USA
&
P. H. Finne Pediatric Research Institute, Rikshospitalet, Oslo, Norway; Department of Urology, University of Washington Medical School, Seattle, Washington, USA
Pages 63-66 | Received 27 Dec 1971, Accepted 18 May 1972, Published online: 08 Jul 2009
 
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Abstract

Urinary erythropoietin levels were measured in two normal dogs before and after probenecid administration (25 mg/kg/day). Decrased urinary erythropoietin excretion was noted in those dogs receiving the drug. This would indicate that the secretion of erythropoietin was blocked at the site of action of the probenecid, the proximal convoluted tubules.

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