Abstract
Glucose infusion gave no increase of glycogen nor of synthetase I activity in muscle of diabetics at rest, contrary to in normals. After glycogen depletion by exercise, high I activity was seen in both normals and diabetics, and glycogen synthesis was observed during glucose infusion. While glycogen increased, I activity tended to fall. Insulin during infusion apparently affected neither the glycogen synthesis rate nor the I activity in normals, but did increase the I activity and the glycogen synthesis rate in diabetics, most pronouncedly in insulin-dependent patients.