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Original Article

Muscle Glycogen and Glycogen Synthetase in Normal Subjects and in Patients with Diabetes Mellitus Effect of Intravenous Glucose and Insulin Administration

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Pages 77-84 | Received 09 Apr 1972, Accepted 23 May 1972, Published online: 13 May 2010
 

Abstract

Glucose infusion gave no increase of glycogen nor of synthetase I activity in muscle of diabetics at rest, contrary to in normals. After glycogen depletion by exercise, high I activity was seen in both normals and diabetics, and glycogen synthesis was observed during glucose infusion. While glycogen increased, I activity tended to fall. Insulin during infusion apparently affected neither the glycogen synthesis rate nor the I activity in normals, but did increase the I activity and the glycogen synthesis rate in diabetics, most pronouncedly in insulin-dependent patients.

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