Abstract
The authors report the concentration of some plasma proteins after administration of mestranol and/or chlormadinone in 19 controls and 43 women who had had recurrent cholestasis during previous pregnancies. Mestranol alone and combined with chlormadinone acetate induced enhanced βIC-globulin and fibrinogen and depressed cold insoluble globulin level. The changes were, if anything, more marked in women with cholestasis during an earlier pregnancy. No change of antichymotrypsin or C-reactive proteins was found in any of the groups. Chlormadinone acetate alone produced no apparent alterations in the plasma protein pattern.